AMPATH Lab: Focused Cancer Panel

How a Focused Hereditary Cancer Panel Helps Identify Your Genetic Cancer Risk

Understanding your hereditary cancer risk is an important part of proactive health management. While family history can offer helpful clues, it may not always provide the full picture. A Focused Hereditary Cancer Panel bridges this gap by examining specific genes known to increase the risk of certain cancers. This targeted approach delivers clear, actionable insights for you and your healthcare provider.

A Focused Hereditary Cancer Panel is designed to detect mutations in a curated set of genes linked to hereditary cancers. Unlike broad-spectrum genetic tests that examine many genes, a focused panel concentrates only on the genes most relevant to your medical and family history. This makes the analysis more precise, efficient, and cost-effective.

What is a Focused Hereditary Cancer Panel?

This panel is a specialized genetic test that studies selected genes known to increase your risk for specific hereditary cancers. These genes are chosen based on scientific evidence linking them to well-known cancer syndromes such as Lynch syndrome or Hereditary Breast and Ovarian Cancer (HBOC) syndrome.

The primary purpose of this targeted testing is to provide a precise and reliable risk assessment without the complexity that comes with broader genetic testing.

How a Focused Panel Differs from Other Genetic Tests

Multi-Gene Panels: Test many genes at once and may lead to a higher chance of uncertain results (VUS).
Whole Exome/Genome Sequencing: Examines nearly all genes; often used in research or complex medical cases due to cost and complexity.

A focused panel is ideal for individuals whose personal or family history points to a known hereditary cancer syndrome. It delivers clinically reliable and easy-to-interpret results.

Benefits of a Targeted Approach

Increased Clinical Relevance

Actionable Results: Mutations found in high-risk genes like BRCA1, BRCA2 clearly guide preventive and screening decisions.
Established Guidelines: Medical societies provide clear management plans for most genes included in focused panels.

Reduced Ambiguity

Lower VUS Rates: Focused panels limit testing to well-understood genes, reducing uncertain findings.
Clearer Interpretation: Results are easier for both patients and providers to understand and act upon.

Cost and Time Efficiency

Lower Cost: Testing fewer genes reduces laboratory costs.
Faster Turnaround: Results are typically available sooner due to targeted analysis.

The Process of Undergoing a Focused Panel

Step 1: Genetic Counseling and Consultation

Review of personal and family medical history
Explanation of which genes will be analyzed
Understanding possible results (positive, negative, VUS)
Providing informed consent

Step 2: Sample Collection

Usually a simple blood or saliva sample
Collected in a certified clinic or laboratory

Step 3: Laboratory Analysis

DNA extraction from your sample
Sequencing of selected genes to detect mutations
Expert interpretation of findings

Step 4: Receiving and Understanding Your Results

Positive Result: A high-risk mutation is found; your healthcare team will recommend screening or prevention strategies.
Negative Result: No mutation detected; general cancer screening guidelines still apply.
Variant of Uncertain Significance (VUS): The impact of the genetic change is unknown; no medical decisions are made based on a VUS.

Conclusion

A Focused Hereditary Cancer Panel provides a powerful, precise way to understand your inherited cancer risks. By delivering actionable results and minimizing uncertainty, it empowers you and your healthcare provider to create a personalized health management plan. If you have a personal or family history of cancer, discussing focused genetic testing with a specialist is an important step toward proactive, informed healthcare.